High-sensitivity C-reactive protein is associated with clonal hematopoiesis of indeterminate potential

Copy number alterations detected as clonal hematopoiesis of indeterminate potential.

Recent studies have revealed that clonal hematopoiesis of indeterminate potential (CHIP) is an important risk factor for therapy-related myeloid neoplasms (t-MNs). CHIP is currently defined as a clonal hematopoietic population carrying somatic point mutations in 1 of the leukemia-associated genes. Patients with t-MNs often present with chromosomal abnormalities in addition to somatic point muta...

Problems with high-sensitivity C-reactive protein.

To the Editor: Last year, Ockene et al. (1) published a report in this journal that made the claim that high-sensitivity C-reactive protein (hs-CRP) has a degree of measurement stability that is similar to that of total cholesterol and that this provides further evidence of the potential clinical utility of hs-CRP screening as a novel tool for vascular risk prediction. The key evidence that Ock...

High-Sensitivity C-Reactive Protein and Cancer

BACKGROUND High-sensitivity C-reactive protein (hs-CRP) is a commonly used inflammatory marker. The association between hs-CRP and cancer is less consistent than that between hs-CRP and cardiovascular diseases. This study explored the association between hs-CRP and cancer, using a large database of Korean health examination records. METHODS A total of 80,781 Koreans who visited the health pro...

High-sensitivity C-reactive protein methods examined.

Steatosis DeLIVERs high-sensitivity C-reactive protein.

Nonalcoholic fatty liver disease is characterized by excess accumulation of lipids within parenchymal cells of the liver (ie, hepatocellular steatosis) in the absence of excessive ethanol consumption. Fatty liver disease is widely considered to be the hepatic manifestation of metabolic syndrome and is estimated to occur in more than 25% of the Western population.1 Nonalcoholic fatty liver disea...